Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 20/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13677494 | 1.00 | TACR1 (0.73) | TACR1KCNH2NR1I2 | |
| SCHEMBL7202907 | 1.00 | TACR1 (0.73) | TACR1KCNH2NR1I2 | |
| SCHEMBL7202912 | 1.00 | TACR1 (0.73) | TACR1KCNH2NR1I2 | |
| SCHEMBL13677467 | 1.00 | TACR1 (0.73) | TACR1KCNH2NR1I2 | |
| SCHEMBL3174650 | 0.93 | TACR1 (0.69) | TACR1KCNH2 | |
| SCHEMBL5117793 | 0.93 | TACR1 (0.69) | TACR1KCNH2 | |
| SCHEMBL13677491 | 0.92 | TACR1 (0.70) | TACR1KCNH2NR1I2 | |
| SCHEMBL13677490 | 0.92 | TACR1 (0.70) | TACR1KCNH2NR1I2 | |
| SCHEMBL13677460 | 0.92 | TACR1 (0.70) | TACR1KCNH2NR1I2 | |
| SCHEMBL7198877 | 0.91 | TACR1 (0.63) | TACR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937264-B1 | COMBINATION THERAPY FOR THE TREATMENT OF URINARY FREQUENCY, URINARY URGENCY AND URINARY INCONTINENCE | MERCK SHARP & DOHME (US) | 2011-06-08 | — | — | EP | disclosed |
| US-7893091-B2 | Combination therapy for the treatment of urinary frequency, urinary urgency and urinary incontinence | MERCK SHARP & DOHME CORP. (US) | 2011-02-22 | — | — | US | disclosed |
| US-20090270406-A1 | Combination Therapy for the Treatment of Urinary Frequency, Urinary Urgency and Urinary Incontinence | MERCK SHARP & DOHME CORP. | 2009-10-29 | — | — | US | disclosed |
| US-20090247770-A1 | PROCESS FOR MAKING LACTAM TACHYKININ RECEPTOR ANTAGONISTS | MSD K.K. (JP) | 2009-10-01 | — | — | US | disclosed |
| US-20090247770-A1 | PROCESS FOR MAKING LACTAM TACHYKININ RECEPTOR ANTAGONISTS | MSD K.K. (JP) | 2009-10-01 | — | — | US | disclosed |
| WO-2008021029-A2 | PROCESS FOR MAKING LACTAM TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| WO-2007146224-A2 | COMBINATION THERAPY FOR THE TREATMENT OF URINARY FREQUENCY, URINARY URGENCY AND URINARY INCONTINENCE | MERCK & CO., INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| US-7196113-B2 | Lactam tachykinin receptor antagonists | MERCK & CO., INC. (US) | 2007-03-27 | — | — | US | disclosed |
| US-20050282886-A1 | Lactam tachykinin receptor antagonists | MERCK SHARP & DOHME CORP. | 2005-12-22 | — | — | US | disclosed |
| EP-1322596-A1 | ZWITTERIONIC TACHYKININ RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2003-07-02 | — | — | EP | disclosed |
| US-6479518-B2 | PSYCHOLOGICAL DISORDERS | MERCK & CO., INC. | 2002-11-12 | — | — | US | disclosed |
| US-20020042431-A1 | Zwitterionic tachykinin receptor antagonists | MERCK & CO., INC. | 2002-04-11 | — | — | US | disclosed |
| WO-2002024629-A1 | ZWITTERIONIC TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020042431-A1 | Zwitterionic tachykinin receptor antagonists | NPY5R, NPY1R, NPY2R | TACR1 11/4885KCNH2 263/4885NR1I2 1812/4885 |
| US-20090247770-A1 | PROCESS FOR MAKING LACTAM TACHYKININ RECEPTOR ANTAGONISTS | TACR1, TACR2, NPSR1 | TACR1 1/4885KCNH2 239/4885NR1I2 1356/4885 |
| US-20090270406-A1 | Combination Therapy for the Treatment of Urinary Frequency, Urinary Urgency and Urinary Incontinence | MME, UTS2R, BPHL | TACR1 7/4885KCNH2 1764/4885NR1I2 2118/4885 |
| US-20050282886-A1 | Lactam tachykinin receptor antagonists | TACR1, TACR2, NPSR1 | TACR1 1/4885KCNH2 254/4885NR1I2 2204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.