Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2688734 | 0.79 | PIM1 (0.66) | MAPK8MAPK9MAPK10PIM1PIM2 | |
| SCHEMBL12768370 | 0.79 | PIM1 (0.45) | PIM1PIM2KDM4EPKN1PKN2 | |
| SCHEMBL10136673 | 0.79 | PIM1 (0.63) | MAPK8MAPK9MAPK10PIM1PIM2 | |
| SCHEMBL1527651 | 0.79 | PIM1 (0.50) | PIM1PIM2KDM4EPKN1PKN2 | |
| SCHEMBL528027 | 0.79 | KDM4E (0.50) | PIM1PIM2KDM4EKMT2AGAA | |
| SCHEMBL12768371 | 0.77 | TP53 (0.46) | PIM1PIM2KDM4EKMT2AGAA | |
| SCHEMBL12768673 | 0.77 | PIM1 (0.45) | PIM1PIM2KDM4EPKN1PKN2 | |
| SCHEMBL12768684 | 0.76 | KDM4E (0.42) | PIM1PIM2KDM4EPKN1PKN2 | |
| SCHEMBL526632 | 0.76 | KDM4E (0.44) | MAPK8MAPK9MAPK10PIM1PIM2 | |
| SCHEMBL527171 | 0.76 | KDM4E (0.47) | PIM1PIM2KDM4EPKN1PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110065698-A1 | NOVEL PROTEIN KINASE MODULATORS | CYLENE PHARMACEUTICALS, INC. (US) | 2011-03-17 | — | — | US | disclosed |
| US-20110065698-A1 | NOVEL PROTEIN KINASE MODULATORS | CYLENE PHARMACEUTICALS, INC. (US) | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065698-A1 | NOVEL PROTEIN KINASE MODULATORS | PIM2, PIM1, PIM3 | MAPK8 678/4885MAPK9 779/4885MAPK10 1107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.