Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 8/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.36 |
| ▸ | PDE4A | P27815 | 7/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.31 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.31 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL127633 | 0.93 | PDE4D (0.35) | PDE4DPDE4BPDE4APDE4CNPSR1 | |
| SCHEMBL127526 | 0.90 | ACSL1 (0.35) | PDE4DPDE4BPDE4APDE4CNPSR1 | |
| SCHEMBL129648 | 0.89 | MAPT (0.35) | PDE4DPDE4BPDE4APDE4CNPSR1 | |
| SCHEMBL129377 | 0.87 | MAPT (0.36) | PDE4DPDE4BPDE4APDE4CNPSR1 | |
| SCHEMBL129304 | 0.86 | MAPT (0.36) | PDE4DPDE4BPDE4APDE4CNPSR1 | |
| SCHEMBL129263 | 0.86 | MAPT (0.34) | PDE4DPDE4BPDE4APDE4CNPSR1 | |
| SCHEMBL129029 | 0.70 | PDE4A (0.35) | PDE4DPDE4BPDE4APDE4CSLC16A3 | |
| SCHEMBL129675 | 0.69 | SMN1; SMN2 (0.38) | MAPTALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL130087 | 0.69 | CYP2C9 (0.35) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL128765 | 0.68 | CYP2C9 (0.35) | PDE4DPDE4BPDE4APDE4CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450319-B2 | Pyrrolopyridazinone compound | UBE INDUSTRIES, LTD. (JP) | 2013-05-28 | — | — | US | disclosed |
| EP-1982986-B1 | PYRROLOPYRIDAZINONE COMPOUND AS PDE4 INHIBITOR | UBE INDUSTRIES (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-20090036453-A1 | Pyrrolopyridazinone Compound | UBE INDUSTRIES, LTD. (JP) | 2009-02-05 | — | — | US | disclosed |
| EP-1982986-A1 | PYRROLOPYRIDAZINONE COMPOUND | Ube Industries, Ltd. (JP) | 2008-10-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036453-A1 | Pyrrolopyridazinone Compound | CBR3, CBR1, CYC1 | PDE4D 3827/4885PDE4B 3261/4885PDE4A 3035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.