Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 4/20 | 0.45 |
| ▸ | ZAP70 | P43403 | 8/20 | 0.41 |
| ▸ | FER | P16591 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1158258 | 1.00 | JAK2 (0.48) | JAK2JAK1SYKZAP70FER | |
| SCHEMBL1158632 | 1.00 | JAK2 (0.48) | JAK2JAK1SYKZAP70FER | |
| SCHEMBL1160124 | 0.87 | JAK2 (0.47) | JAK2JAK1SYKZAP70FER | |
| SCHEMBL1159861 | 0.80 | PIK3CA (0.48) | JAK2JAK1SYKZAP70 | |
| SCHEMBL1159703 | 0.80 | ZAP70 (0.44) | JAK2JAK1SYKZAP70 | |
| SCHEMBL1046775 | 0.78 | ZAP70 (0.56) | JAK2SYKZAP70 | |
| SCHEMBL1158525 | 0.78 | SYK (0.45) | SYKZAP70 | |
| SCHEMBL1158587 | 0.78 | ZAP70 (0.44) | JAK2JAK1SYKZAP70 | |
| SCHEMBL1157977 | 0.77 | SYK (0.55) | JAK2SYKZAP70 | |
| SCHEMBL13752674 | 0.75 | ZAP70 (0.57) | ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110053897-A1 | COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS | IRM LLC (BM) | 2011-03-03 | — | — | US | disclosed |
| US-20110053897-A1 | COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS | IRM LLC (BM) | 2011-03-03 | — | — | US | disclosed |
| WO-2011014515-A1 | 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS | IRM LLC (BM) | 2011-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053897-A1 | COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS | SYK, BTK, LYN | JAK2 19/4885JAK1 42/4885SYK 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.