Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 17/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1158494 | 0.93 | SYK (0.55) | SYKNOS1NOS2BRD4ATAD2 | |
| SCHEMBL1158342 | 0.89 | SYK (0.51) | SYKNOS1NOS2BRD4ATAD2 | |
| SCHEMBL12795849 | 0.89 | SYK (0.62) | SYKNOS1NOS2 | |
| SCHEMBL12795858 | 0.89 | SYK (0.62) | SYKNOS1NOS2 | |
| SCHEMBL1157693 | 0.89 | SYK (0.62) | SYKNOS1NOS2 | |
| SCHEMBL12796042 | 0.86 | SYK (0.60) | SYK | |
| SCHEMBL12795847 | 0.86 | SYK (0.69) | SYKNOS1NOS2 | |
| SCHEMBL12797762 | 0.86 | SYK (0.69) | SYKNOS1NOS2 | |
| SCHEMBL12796370 | 0.86 | SYK (0.44) | SYK | |
| SCHEMBL12796368 | 0.84 | SYK (0.34) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110053897-A1 | COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS | IRM LLC (BM) | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053897-A1 | COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS | SYK, BTK, LYN | SYK 1/4885NOS1 737/4885NOS2 772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.