Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.39 |
| ▸ | PDE4A | P27815 | 7/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL129033 | 0.92 | PDE4D (0.40) | PTGS1PTGS2PDE4DPDE4BPDE4A | |
| SCHEMBL129474 | 0.84 | PDE4B (0.39) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL128302 | 0.83 | PDE4D (0.38) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL128932 | 0.83 | PDE4A (0.37) | PTGS1PTGS2PDE4DPDE4BPDE4A | |
| SCHEMBL127181 | 0.78 | PDE4D (0.39) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL128317 | 0.77 | PDE4A (0.34) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL127472 | 0.76 | PDE4A (0.33) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL129131 | 0.76 | PDE4A (0.33) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL128475 | 0.75 | PDE4B (0.31) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL130461 | 0.75 | PDE4D (0.30) | PDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450319-B2 | Pyrrolopyridazinone compound | UBE INDUSTRIES, LTD. (JP) | 2013-05-28 | — | — | US | disclosed |
| EP-1982986-B1 | PYRROLOPYRIDAZINONE COMPOUND AS PDE4 INHIBITOR | UBE INDUSTRIES (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-20090036453-A1 | Pyrrolopyridazinone Compound | UBE INDUSTRIES, LTD. (JP) | 2009-02-05 | — | — | US | disclosed |
| EP-1982986-A1 | PYRROLOPYRIDAZINONE COMPOUND | Ube Industries, Ltd. (JP) | 2008-10-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036453-A1 | Pyrrolopyridazinone Compound | CBR3, CBR1, CYC1 | PTGS1 374/4885PTGS2 447/4885PDE4D 3827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.