Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 14/20 | 0.48 |
| ▸ | JAK1 | P23458 | 12/20 | 0.48 |
| ▸ | JAK2 | O60674 | 9/20 | 0.48 |
| ▸ | TYK2 | P29597 | 6/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | FLT4 | P35916 | 2/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12795971 | 0.91 | JAK3 (0.53) | LRRK2JAK3JAK1JAK2TYK2 | |
| SCHEMBL12797155 | 0.87 | JAK3 (0.50) | LRRK2JAK3JAK1JAK2TYK2 | |
| SCHEMBL12797497 | 0.87 | JAK3 (0.61) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL12796248 | 0.87 | JAK1 (0.51) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL12796241 | 0.85 | LRRK2 (0.52) | LRRK2JAK3JAK1JAK2TYK2 | |
| SCHEMBL1665150 | 0.85 | JAK3 (0.58) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL12796414 | 0.84 | JAK3 (0.46) | LRRK2JAK3JAK1JAK2TYK2 | |
| SCHEMBL1662838 | 0.83 | JAK3 (0.48) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL12797293 | 0.82 | JAK3 (0.49) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL12797285 | 0.82 | JAK1 (0.50) | JAK3JAK1JAK2TYK2FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242987-B2 | Heterocyclyl pyrazolopyrimidine analogues as JAK inhibitors | CELLZOME LIMITED (GB) | 2016-01-26 | — | — | US | claimed |
| US-20120252779-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2012-10-04 | — | — | US | claimed |
| US-9242987-B2 | Heterocyclyl pyrazolopyrimidine analogues as JAK inhibitors | CELLZOME LIMITED (GB) | 2016-01-26 | — | — | US | disclosed |
| US-9242987-B2 | Heterocyclyl pyrazolopyrimidine analogues as JAK inhibitors | CELLZOME LIMITED (GB) | 2016-01-26 | — | — | US | disclosed |
| US-20120252779-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2012-10-04 | — | — | US | disclosed |
| US-20120252779-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2012-10-04 | — | — | US | disclosed |
| WO-2011048082-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252779-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | JAK1, JAK3, JAK2 | LRRK2 2904/4885JAK3 2/4885JAK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.