Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 13/20 | 0.72 |
| ▸ | AURKA | O14965 | 3/20 | 0.72 |
| ▸ | PLK4 | O00444 | 2/20 | 0.72 |
| ▸ | STK16 | O75716 | 2/20 | 0.72 |
| ▸ | RET | P07949 | 2/20 | 0.72 |
| ▸ | FLT3 | P36888 | 2/20 | 0.72 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.72 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.72 |
| ▸ | MST1R | Q04912 | 2/20 | 0.72 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.72 |
| ▸ | TNK1 | Q13470 | 2/20 | 0.72 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.72 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.72 |
| ▸ | ADCK1 | Q86TW2 | 2/20 | 0.72 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.72 |
| ▸ | NEK9 | Q8TD19 | 2/20 | 0.72 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.72 |
| ▸ | IRAK3 | Q9Y616 | 2/20 | 0.72 |
| ▸ | LATS1 | O95835 | 1/20 | 0.72 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4108129 | 0.94 | SYK (0.81) | SYKAURKAPLK4STK16RET | |
| SCHEMBL2627470 | 0.93 | SYK (0.75) | SYKAURKAPLK4STK16RET | |
| SCHEMBL11937337 | 0.90 | SYK (0.89) | SYKAURKAPLK4STK16RET | |
| SCHEMBL11937336 | 0.89 | SYK (0.67) | SYKAURKAPLK4STK16RET | |
| SCHEMBL16682499 | 0.87 | SYK (0.80) | SYKAURKAPLK4STK16RET | |
| SCHEMBL13451897 | 0.86 | SYK (0.84) | SYKAURKAPLK4STK16RET | |
| SCHEMBL2627484 | 0.86 | SYK (0.84) | SYKAURKAPLK4STK16RET | |
| SCHEMBL15397396 | 0.85 | SYK (0.64) | SYKAURKAPLK4STK16RET | |
| SCHEMBL20006821 | 0.85 | SYK (0.82) | SYKAURKAPLK4STK16RET | |
| SCHEMBL28489482 | 0.85 | SYK (0.84) | SYKAURKAPLK4STK16RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170291909-A1 | Prodrugs of 2,4-Pyrimidinediamine Compounds and Their Uses | RIGEL PHARMACEUTICALS, INC. (US) | 2017-10-12 | — | — | US | disclosed |
| US-8481521-B2 | Methods of treating cell proliferative disorders | RIGEL PHARMACEUTICALS, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-8481521-B2 | Methods of treating cell proliferative disorders | RIGEL PHARMACEUTICALS, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-20120245127-A1 | Methods of Treating Cell Proliferative Disorders | RIGEL PHARMACEUTICALS, INC. (US) | 2012-09-27 | — | — | US | disclosed |
| US-7449458-B2 | Autoimmune diseases; water solubility of prodrug can be tailored to improve bioavailability using substution at amine groups; inhibitors of degranulation of immune cells; inhibit/activate Fc receptor signaling cascades; tyrosine kinase Syk kinase inhibitor; collagen-induced platelet activation inhibitor | RIGEL PHARMACEUTICALS, INC. (US) | 2008-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245127-A1 | Methods of Treating Cell Proliferative Disorders | MKI67, SYK, TP53 | SYK 2/4885AURKA 723/4885PLK4 129/4885 |
| US-20170291909-A1 | Prodrugs of 2,4-Pyrimidinediamine Compounds and Their Uses | DPYD, TYMP, DCTD | SYK 2055/4885AURKA 617/4885PLK4 909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.