Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.65 |
| ▸ | JAK3 | P52333 | 12/20 | 0.60 |
| ▸ | TYK2 | P29597 | 5/20 | 0.57 |
| ▸ | JAK1 | P23458 | 5/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | CIT | O14578 | 1/20 | 0.55 |
| ▸ | GAK | O14976 | 1/20 | 0.55 |
| ▸ | OPA1 | O60313 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | STK16 | O75716 | 1/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12800910 | 0.93 | JAK2 (0.67) | JAK2JAK3TYK2JAK1HDAC1 | |
| SCHEMBL12801337 | 0.90 | JAK2 (0.69) | JAK2JAK3TYK2JAK1HDAC1 | |
| SCHEMBL1667298 | 0.88 | JAK2 (0.61) | JAK2JAK3TYK2JAK1HDAC1 | |
| SCHEMBL12800357 | 0.87 | JAK2 (0.57) | JAK2JAK3TYK2JAK1HDAC1 | |
| SCHEMBL12801615 | 0.85 | JAK2 (0.69) | JAK2JAK3TYK2JAK1HDAC1 | |
| SCHEMBL12801310 | 0.85 | JAK2 (0.72) | JAK2JAK3TYK2JAK1HDAC1 | |
| SCHEMBL12801590 | 0.84 | JAK2 (0.66) | JAK2JAK3TYK2JAK1HDAC1 | |
| SCHEMBL12801653 | 0.84 | JAK2 (0.85) | JAK2JAK3TYK2JAK1HDAC1 | |
| SCHEMBL12801297 | 0.84 | JAK2 (0.63) | JAK2JAK3TYK2JAK1HDAC1 | |
| SCHEMBL12801611 | 0.84 | JAK2 (0.70) | JAK2JAK3TYK2JAK1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |