Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.76 |
| ▸ | JAK3 | P52333 | 10/20 | 0.65 |
| ▸ | JAK1 | P23458 | 4/20 | 0.62 |
| ▸ | TYK2 | P29597 | 4/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.61 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12800935 | 0.90 | JAK2 (0.69) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL12522201 | 0.90 | JAK2 (0.63) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL12801620 | 0.89 | JAK2 (0.66) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL12801381 | 0.89 | JAK2 (0.62) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL12522331 | 0.88 | JAK2 (0.64) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL12801263 | 0.88 | JAK2 (0.71) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL12522359 | 0.88 | JAK2 (0.61) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL12801354 | 0.87 | JAK2 (0.65) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL12801350 | 0.87 | JAK2 (0.65) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL12274521 | 0.87 | JAK2 (0.72) | JAK2JAK3JAK1TYK2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |