Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.66 |
| ▸ | JAK3 | P52333 | 3/20 | 0.59 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.56 |
| ▸ | PLK4 | O00444 | 2/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.53 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | TYK2 | P29597 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801564 | 0.92 | JAK2 (0.63) | JAK2JAK3MAPK8MAPK10MYLK4 | |
| SCHEMBL12800904 | 0.90 | JAK2 (0.70) | JAK2JAK3SMG1MYLK4STK17A | |
| SCHEMBL12801241 | 0.88 | JAK2 (0.68) | JAK2JAK3SMG1PLK4MAPK8 | |
| SCHEMBL12276953 | 0.87 | JAK2 (0.61) | JAK2JAK3SMG1PLK4MAPK8 | |
| SCHEMBL12801572 | 0.86 | JAK2 (0.69) | JAK2JAK3MYLK4STK17AHDAC3 | |
| SCHEMBL12801615 | 0.86 | JAK2 (0.69) | JAK2JAK3MYLK4STK17AHDAC3 | |
| SCHEMBL12801653 | 0.85 | JAK2 (0.85) | JAK2JAK3PLK4MAPK8MAPK10 | |
| SCHEMBL12801611 | 0.85 | JAK2 (0.70) | JAK2JAK3PLK4MAPK8MAPK10 | |
| SCHEMBL12800919 | 0.85 | JAK2 (0.67) | JAK2JAK3HDAC3NCOR1JAK1 | |
| SCHEMBL12801607 | 0.84 | PLK4 (0.65) | JAK2JAK3SMG1PLK4MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |