Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.72 |
| ▸ | JAK3 | P52333 | 8/20 | 0.64 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.55 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.55 |
| ▸ | JAK1 | P23458 | 2/20 | 0.55 |
| ▸ | TYK2 | P29597 | 2/20 | 0.55 |
| ▸ | CDK2 | P24941 | 2/20 | 0.55 |
| ▸ | CDC7 | O00311 | 1/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | CIT | O14578 | 1/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | GAK | O14976 | 1/20 | 0.55 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.55 |
| ▸ | BUB1 | O43683 | 1/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801590 | 0.90 | JAK2 (0.66) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL12801653 | 0.90 | JAK2 (0.85) | JAK2JAK3STK17AMYLK4JAK1 | |
| SCHEMBL12801611 | 0.89 | JAK2 (0.70) | JAK2JAK3STK17AMYLK4JAK1 | |
| SCHEMBL12801091 | 0.89 | JAK2 (0.67) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL12801310 | 0.87 | JAK2 (0.72) | JAK2JAK3STK17AMYLK4JAK1 | |
| SCHEMBL14254075 | 0.87 | JAK2 (0.66) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL1667419 | 0.86 | JAK2 (0.65) | JAK2JAK3JAK1TYK2CDK2 | |
| SCHEMBL12801542 | 0.85 | JAK2 (0.65) | JAK2JAK3STK17AMYLK4JAK1 | |
| SCHEMBL12801273 | 0.85 | JAK2 (0.78) | JAK2JAK3STK17AMYLK4JAK1 | |
| SCHEMBL12801615 | 0.85 | JAK2 (0.69) | JAK2JAK3STK17AMYLK4JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |