Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 11/20 | 0.53 |
| ▸ | CDK2 | P24941 | 11/20 | 0.53 |
| ▸ | CDK1 | P06493 | 10/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 9/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.53 |
| ▸ | CCNB2 | O95067 | 6/20 | 0.53 |
| ▸ | CCNB3 | Q8WWL7 | 6/20 | 0.53 |
| ▸ | CCNE2 | O96020 | 6/20 | 0.53 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.46 |
| ▸ | CDK7 | P50613 | 5/20 | 0.46 |
| ▸ | CDK4 | P11802 | 3/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.46 |
| ▸ | CCND1 | P24385 | 3/20 | 0.46 |
| ▸ | CCND3 | P30281 | 3/20 | 0.46 |
| ▸ | CDK3 | Q00526 | 3/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12802007 | 0.90 | EIF2AK4 (0.53) | CDK9CDK2CDK1CCNT1CDK5R1 | |
| SCHEMBL12797028 | 0.88 | EIF2AK4 (0.51) | CDK9CDK2CDK1CCNT1CDK5R1 | |
| SCHEMBL1662594 | 0.88 | CDK2 (0.54) | CDK9CDK2CDK1CCNT1CDK5R1 | |
| SCHEMBL1662621 | 0.85 | EIF2AK4 (0.52) | CDK9CDK2CDK1CCNT1CDK5R1 | |
| SCHEMBL12801973 | 0.85 | EIF2AK4 (0.55) | CDK9CDK2CDK1CCNT1CDK5R1 | |
| SCHEMBL12801962 | 0.84 | CDK2 (0.46) | CDK9CDK2CDK1CCNT1CDK5R1 | |
| SCHEMBL12797139 | 0.83 | EIF2AK4 (0.48) | CDK9CDK2CCNE1EIF2AK4ALK | |
| SCHEMBL12797314 | 0.83 | EIF2AK4 (0.56) | CDK9CDK2EIF2AK4ALKCDK7 | |
| SCHEMBL12796009 | 0.83 | EIF2AK4 (0.56) | CDK9CDK2EIF2AK4ALKCDK7 | |
| SCHEMBL2585171 | 0.83 | EIF2AK4 (0.55) | CDK9CDK2EIF2AK4ALKCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242987-B2 | Heterocyclyl pyrazolopyrimidine analogues as JAK inhibitors | CELLZOME LIMITED (GB) | 2016-01-26 | — | — | US | claimed |
| US-20120252779-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2012-10-04 | — | — | US | claimed |
| US-9242987-B2 | Heterocyclyl pyrazolopyrimidine analogues as JAK inhibitors | CELLZOME LIMITED (GB) | 2016-01-26 | — | — | US | disclosed |
| US-9242987-B2 | Heterocyclyl pyrazolopyrimidine analogues as JAK inhibitors | CELLZOME LIMITED (GB) | 2016-01-26 | — | — | US | disclosed |
| US-9242987-B2 | Heterocyclyl pyrazolopyrimidine analogues as JAK inhibitors | CELLZOME LIMITED (GB) | 2016-01-26 | — | — | US | disclosed |
| US-20120252779-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2012-10-04 | — | — | US | disclosed |
| US-20120252779-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2012-10-04 | — | — | US | disclosed |
| US-20120252779-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2012-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252779-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | JAK1, JAK3, JAK2 | CDK9 130/4885CDK2 198/4885CDK1 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.