Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 7/20 | 0.40 |
| ▸ | STAT6 | P42226 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 5/20 | 0.38 |
| ▸ | TYK2 | P29597 | 5/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801909 | 0.91 | JAK3 (0.44) | JAK3JAK2STAT6JAK1TYK2 | |
| SCHEMBL12796127 | 0.90 | JAK3 (0.46) | JAK3CDK4CCND1CDK6SYK | |
| SCHEMBL1662524 | 0.88 | STAT6 (0.51) | JAK3CDK4CCND1JAK2STAT6 | |
| SCHEMBL672851 | 0.85 | JAK3 (0.49) | JAK3CDK4CCND1JAK2STAT6 | |
| SCHEMBL10204067 | 0.85 | JAK3 (0.49) | JAK3CDK4CCND1JAK2STAT6 | |
| SCHEMBL672656 | 0.84 | JAK3 (0.46) | JAK3JAK2STAT6JAK1TYK2 | |
| SCHEMBL671882 | 0.83 | JAK3 (0.50) | JAK3TTKJAK2JAK1TYK2 | |
| SCHEMBL672966 | 0.83 | JAK3 (0.48) | JAK3CDK4CCND1JAK2STAT6 | |
| SCHEMBL10205374 | 0.82 | JAK3 (0.49) | JAK3JAK2STAT6JAK1TYK2 | |
| SCHEMBL15122452 | 0.82 | JAK3 (0.44) | JAK3JAK2STAT6JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242987-B2 | Heterocyclyl pyrazolopyrimidine analogues as JAK inhibitors | CELLZOME LIMITED (GB) | 2016-01-26 | — | — | US | disclosed |
| US-20120252779-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2012-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252779-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | JAK1, JAK3, JAK2 | JAK3 2/4885TTK 844/4885CDK4 229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.