Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 5/20 | 0.62 |
| ▸ | PAK4 | O96013 | 4/20 | 0.62 |
| ▸ | PAK1 | Q13153 | 6/20 | 0.59 |
| ▸ | PAK2 | Q13177 | 5/20 | 0.53 |
| ▸ | PAK3 | O75914 | 3/20 | 0.53 |
| ▸ | WEE1 | P30291 | 1/20 | 0.52 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.50 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 6/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13553533 | 0.92 | PKN1 (0.66) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL12807722 | 0.87 | PKN1 (0.57) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL13554017 | 0.87 | PKN1 (0.60) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL13554015 | 0.86 | PAK1 (0.59) | PKN1PAK4PAK1PAK2PAK3 | |
| Hydrochloric Acid SCHEMBL1681161 | 0.85 | PAK1 (0.58) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL13553531 | 0.84 | PKN1 (0.76) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL1680969 | 0.83 | PAK1 (0.85) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL16511853 | 0.83 | PKN1 (0.54) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL16511846 | 0.82 | PKN1 (0.54) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL15785341 | 0.82 | PKN1 (0.55) | PKN1PAK4PAK1PAK2PAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011044535-A2 | 8-ETHYL-6-(ARYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | AFRAXIS, INC. (US) | 2011-04-14 | — | — | WO | disclosed |