Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 2/20 | 0.33 |
| ▸ | BIRC3 | Q13489 | 2/20 | 0.33 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | FPR2 | P25090 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11984181 | 0.93 | ADRB3 (0.36) | ADRB3ADRA2BADRA2CF2F10 | |
| SCHEMBL11984121 | 0.92 | GAA (0.36) | ADRB3ADRA2BADRA2CF2F10 | |
| SCHEMBL13059758 | 0.92 | GAA (0.36) | ADRB3ADRA2BADRA2CF2F10 | |
| SCHEMBL7999967 | 0.92 | ADRB3 (0.42) | ADRB3ADRA2BADRA2CF2F10 | |
| SCHEMBL8378473 | 0.92 | ADRB3 (0.42) | ADRB3ADRA2BADRA2CF2F10 | |
| SCHEMBL1645865 | 0.92 | ADRB3 (0.42) | ADRB3ADRA2BADRA2CF2F10 | |
| SCHEMBL1645862 | 0.92 | ADRB3 (0.42) | ADRB3ADRA2BADRA2CF2F10 | |
| SCHEMBL13059226 | 0.92 | ADRB3 (0.42) | ADRB3ADRA2BADRA2CF2F10 | |
| SCHEMBL8237408 | 0.92 | ADRB3 (0.42) | ADRB3ADRA2BADRA2CF2F10 | |
| SCHEMBL1645860 | 0.92 | ADRB3 (0.42) | ADRB3ADRA2BADRA2CF2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299021-B2 | Macrocyclic inhibitors of hepatitis C virus replication | INTERMUNE, INC. (US) | 2012-10-30 | — | — | US | disclosed |
| EP-2305697-A2 | Macrocyclic inhibitors of Hepatitis C virus replication | Intermune, Inc. (US) | 2011-04-06 | — | — | EP | disclosed |