Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 11/20 | 0.49 |
| ▸ | KHK | P50053 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 2/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | RBP4 | P02753 | 2/20 | 0.40 |
| ▸ | TTR | P02766 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1410530 | 0.90 | NOTUM (0.53) | NOTUMKHKRBP4TTR | |
| SCHEMBL1409534 | 0.81 | NOTUM (0.65) | NOTUMKHKACACBRBP4TTR | |
| SCHEMBL1410227 | 0.75 | NOTUM (0.66) | NOTUMKHK | |
| SCHEMBL1410132 | 0.72 | NOTUM (0.58) | NOTUM | |
| SCHEMBL2940577 | 0.72 | NOTUM (0.44) | NOTUM | |
| SCHEMBL22186378 | 0.72 | NOTUM (0.50) | NOTUMKHK | |
| SCHEMBL28593065 | 0.72 | NOTUM (0.51) | NOTUMACACBUSP30 | |
| SCHEMBL28593064 | 0.72 | NOTUM (0.51) | NOTUMACACBUSP30 | |
| SCHEMBL1410681 | 0.72 | NOTUM (0.63) | NOTUMKHK | |
| Hydrochloric Acid SCHEMBL28601661 | 0.71 | NOTUM (0.49) | NOTUMKHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295406-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-03-16 | — | — | EP | disclosed |