Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 9/20 | 0.59 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.59 |
| ▸ | TUBB | P07437 | 5/20 | 0.59 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.59 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.59 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.59 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.59 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.59 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.59 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.59 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.59 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.59 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.59 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.59 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.59 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.54 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1425140 | 0.86 | TUBB1 (0.81) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1425136 | 0.86 | TUBB1 (0.81) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL21980878 | 0.83 | TUBB1 (0.80) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3760725 | 0.83 | TUBB1 (0.80) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL12810730 | 0.83 | ABL1 (0.49) | TUBB1ABCB1PDE4APDE4BPDE4C | |
| SCHEMBL1425256 | 0.79 | TUBB1 (0.78) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1425262 | 0.79 | TUBB1 (0.78) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1425363 | 0.76 | TUBB1 (0.76) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1425357 | 0.76 | TUBB1 (0.76) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL12687508 | 0.76 | PDE4A (0.71) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432669-B1 | 4-(C2-6 ALKOXY)-SUBSTITUTED CHALCONES AS THERAPEUTIC AGENTS | SPEAR THERAPEUTICS LTD (GB) | 2011-03-23 | — | — | EP | disclosed |