Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.46 |
| ▸ | MTOR | P42345 | 2/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12812029 | 0.88 | PIK3CA (0.44) | HPGDPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL12812391 | 0.87 | HPGD (0.53) | HPGDPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL3091537 | 0.85 | PIK3CA (0.55) | HPGDPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL1442272 | 0.83 | PIK3CA (0.50) | HPGDPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL1442616 | 0.83 | PIK3CA (0.50) | HPGDPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL12812428 | 0.83 | CDK6 (0.54) | HPGDPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL1444098 | 0.83 | HPGD (0.53) | HPGDPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL1442506 | 0.82 | CLK4 (0.61) | HPGDPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL1441974 | 0.82 | MTOR (0.53) | HPGDPIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL12812023 | 0.82 | HPGD (0.62) | HPGDPIK3CAPIK3CDPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011026579-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-03-10 | — | — | WO | disclosed |