Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 8/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12811951 | 0.90 | HPGD (0.45) | HCRTR1HCRTR2HCAR2PIK3CAHPGD | |
| SCHEMBL12812446 | 0.88 | HPGD (0.49) | ALOX5APHCRTR1HCRTR2HCAR2PIK3CA | |
| SCHEMBL1442702 | 0.85 | CNR2 (0.46) | ALOX5APHCRTR1HCRTR2HCAR2SMN1; SMN2 | |
| SCHEMBL1442934 | 0.83 | PIK3CA (0.49) | HCAR2PIK3CAHPGDPTPN11 | |
| SCHEMBL1442549 | 0.83 | PIK3CA (0.47) | MAPTPIK3CAHPGD | |
| SCHEMBL1442119 | 0.82 | CDK8 (0.47) | MAPTSMN1; SMN2PIK3CAHPGD | |
| SCHEMBL1441972 | 0.81 | HRH3 (0.47) | HCAR2MAPTSMN1; SMN2PIK3CAHPGD | |
| SCHEMBL1442797 | 0.80 | HPGD (0.50) | HCAR2MAPTSMN1; SMN2PIK3CAHPGD | |
| SCHEMBL1442436 | 0.80 | KDM4E (0.48) | MAPTSMN1; SMN2PIK3CAHPGDPTPN11 | |
| SCHEMBL1442484 | 0.79 | HCRTR1 (0.43) | HCRTR1HCRTR2HCAR2MAPTPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011026579-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-03-10 | — | — | WO | disclosed |