Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.64 |
| ▸ | JAK1 | P23458 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 2/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4929537 | 0.89 | PDE4B (0.82) | PDE4BJAK1JAK3ADORA1PDE5A | |
| SCHEMBL8222521 | 0.89 | PDE4B (0.82) | PDE4BJAK1JAK3ADORA1PDE5A | |
| SCHEMBL8230376 | 0.89 | PDE4B (0.82) | PDE4BJAK1JAK3ADORA1PDE5A | |
| SCHEMBL4336092 | 0.89 | PDE4B (0.82) | PDE4BJAK1JAK3ADORA1PDE5A | |
| SCHEMBL4936057 | 0.89 | PDE4B (0.82) | PDE4BJAK1JAK3ADORA1PDE5A | |
| SCHEMBL4336100 | 0.89 | PDE4B (0.82) | PDE4BJAK1JAK3ADORA1PDE5A | |
| SCHEMBL8230122 | 0.88 | PDE4B (0.66) | PDE4BADORA1 | |
| SCHEMBL4934848 | 0.84 | PDE4B (0.63) | PDE4BJAK1JAK3 | |
| SCHEMBL4345680 | 0.84 | PDE4B (0.63) | PDE4BJAK1JAK3 | |
| SCHEMBL14115808 | 0.84 | PDE4B (0.63) | PDE4BJAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940835-B1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LTD (GB) | 2011-03-30 | — | — | EP | disclosed |