Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 15/20 | 0.73 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.73 |
| ▸ | NPC1 | O15118 | 2/20 | 0.73 |
| ▸ | RAB9A | P51151 | 2/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8394304 | 1.00 | EPHX1 (0.73) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19940662 | 1.00 | EPHX1 (0.73) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL966981 | 1.00 | EPHX1 (0.73) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27440890 | 1.00 | EPHX1 (0.73) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL967798 | 0.98 | EPHX1 (0.68) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL968501 | 0.93 | — | — | |
| SCHEMBL18557132 | 0.89 | EPHX1 (0.64) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20938571 | 0.89 | EPHX1 (0.64) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL965099 | 0.87 | — | — | |
| SCHEMBL10155582 | 0.87 | EPHX2 (0.56) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790229-B2 | Bruton's tyrosine kinase inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2017-10-17 | — | — | US | disclosed |
| WO-2011029046-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | BIOGEN IDEC MA INC. (US) | 2011-03-10 | — | — | WO | disclosed |