Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10179606 | 0.91 | SMN1; SMN2 (0.59) | MAPTSMN1; SMN2MAPK1HIF1AEPAS1 | |
| SCHEMBL1442483 | 0.91 | MAPT (0.58) | MAPTSMN1; SMN2MAPK1HIF1AEPAS1 | |
| SCHEMBL27865686 | 0.90 | MAPT (0.47) | MAPTSMN1; SMN2MAPK1HIF1AEPAS1 | |
| SCHEMBL10178972 | 0.90 | SMN1; SMN2 (0.50) | MAPTSMN1; SMN2MAPK1HIF1AEPAS1 | |
| SCHEMBL13276210 | 0.90 | MAPT (0.47) | MAPTSMN1; SMN2MAPK1HIF1AEPAS1 | |
| SCHEMBL10179384 | 0.89 | HIF1A (0.55) | MAPTSMN1; SMN2MAPK1HIF1AEPAS1 | |
| SCHEMBL10180943 | 0.88 | MAPT (0.53) | MAPTSMN1; SMN2MAPK1HIF1AEPAS1 | |
| SCHEMBL10179300 | 0.88 | SLC2A1 (0.53) | MAPTSMN1; SMN2MAPK1HIF1AEPAS1 | |
| SCHEMBL13276228 | 0.88 | HIF1A (0.57) | MAPTSMN1; SMN2MAPK1HIF1AEPAS1 | |
| SCHEMBL13276413 | 0.87 | MAPT (0.47) | MAPTSMN1; SMN2MAPK1HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011026579-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-03-10 | — | — | WO | disclosed |