Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | XBP1 | P17861 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29661791 | 1.00 | AURKB (0.69) | AURKBL3MBTL1HTTSMN1; SMN2GAA | |
| SCHEMBL5349955 | 0.90 | AURKB (0.58) | AURKBL3MBTL1HTTSMN1; SMN2GAA | |
| SCHEMBL1013325 | 0.85 | RXFP1 (0.73) | L3MBTL1HTTSMN1; SMN2GAAMEN1 | |
| SCHEMBL30042580 | 0.85 | RXFP1 (0.73) | L3MBTL1HTTSMN1; SMN2GAAMEN1 | |
| SCHEMBL10845090 | 0.83 | AURKB (0.53) | AURKBMAPTNPSR1ALDH1A1 | |
| SCHEMBL14679395 | 0.83 | HPGD (0.59) | AURKBMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL12464423 | 0.82 | AURKB (0.54) | AURKBSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL15145868 | 0.82 | EGFR (0.68) | AURKBSMN1; SMN2GAAMEN1MAPT | |
| SCHEMBL2472278 | 0.82 | MAPK1 (0.57) | AURKBHTTSMN1; SMN2MEN1MAPT | |
| SCHEMBL21580306 | 0.81 | HTT (0.76) | L3MBTL1HTTSMN1; SMN2GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2508526-A1 | Spiroalkene carboxamide derivatives and their use as chemokine receptor modulators | Ares Trading SA (CH) | 2012-10-10 | — | — | EP | disclosed |
| EP-2508526-A1 | Spiroalkene carboxamide derivatives and their use as chemokine receptor modulators | Ares Trading SA (CH) | 2012-10-10 | — | — | EP | disclosed |
| WO-2012130915-A1 | SPIROALKENE CARBOXAMIDE DERIVATIVES AND THEIR USE AS CHEMOKINE RECEPTOR MODULATORS | ARES TRADING S.A. (CH) | 2012-10-04 | — | — | WO | disclosed |