Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | BRD4 | O60885 | 10/20 | 0.43 |
| ▸ | BRD2 | P25440 | 8/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 8/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12818288 | 0.84 | BRD4 (0.42) | BRD4BRD2BRD3 | |
| SCHEMBL12818294 | 0.83 | PIK3CD (0.47) | MAPTMEN1KMT2ATP53PDE3B | |
| SCHEMBL12818659 | 0.82 | PIK3CD (0.42) | MAPTMEN1KMT2ATP53PDE3B | |
| SCHEMBL12818708 | 0.80 | BRD4 (0.45) | MAPTMEN1KMT2ABRD4BRD2 | |
| SCHEMBL12818903 | 0.79 | MEN1 (0.42) | MAPTMEN1KMT2ATP53PDE3B | |
| SCHEMBL12818435 | 0.79 | KMT2A (0.41) | MAPTMEN1KMT2ATP53PDE3B | |
| SCHEMBL12819204 | 0.79 | PDE3B (0.38) | MAPTMEN1KMT2ATP53PDE3B | |
| SCHEMBL12817588 | 0.78 | PDE3B (0.35) | MAPTMEN1KMT2ATP53PDE3B | |
| SCHEMBL12817586 | 0.78 | PDE3B (0.40) | MAPTMEN1KMT2ATP53PDE3B | |
| SCHEMBL12818632 | 0.77 | PDE3B (0.36) | MAPTMEN1KMT2ATP53PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |