SCHEMBL12818587

SCHEMBL12818587

CN1CCCN(Cc2c(-c3ccc(C#N)cc3)nc3ccc(-c4ccc(C(N)=O)cc4)cn23)CC1

nearest known ligand 0.58

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ SLC2A1 P11166 14/20 0.58
▸ KCNK3 O14649 5/20 0.49
▸ KCNK9 Q9NPC2 5/20 0.49
▸ CYP3A4 P08684 1/20 0.47
▸ MKNK1 Q9BUB5 1/20 0.47
▸ MKNK2 Q9HBH9 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15914075 0.92 SLC2A1 (0.49) SLC2A1KCNK3KCNK9CYP3A4MKNK1
SCHEMBL12818911 0.91 SLC2A1 (0.63) SLC2A1KCNK3KCNK9
SCHEMBL12819423 0.90 SLC2A1 (0.62) SLC2A1KCNK3KCNK9
SCHEMBL12819202 0.89 SLC2A1 (0.74) SLC2A1
SCHEMBL12818892 0.87 SLC2A1 (0.59) SLC2A1KCNK3KCNK9
SCHEMBL12819562 0.87 SLC2A1 (0.70) SLC2A1KCNK3KCNK9
SCHEMBL12818917 0.87 SLC2A1 (0.59) SLC2A1
SCHEMBL12819374 0.87 SLC2A1 (0.59) SLC2A1KCNK3KCNK9
SCHEMBL12819584 0.87 SLC2A1 (0.72) SLC2A1
SCHEMBL12819073 0.87 SLC2A1 (0.58) SLC2A1KCNK3KCNK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140221354-A1 IMIDAZO [1,2-a]PYRIDINE COMPOUNDS FOR USE IN THERAPY EMBLEM TECHNOLOGY TRANSFER GMBH (DE) 2014-08-07 — — US claimed
EP-2691392-A1 IMIDAZO [1,2-A]PYRIDINE COMPOUNDS FOR USE IN THERAPY EMBLEM Technology Transfer GmbH (DE) 2014-02-05 — — EP claimed
WO-2012130322-A1 IMIDAZO [1,2-A]PYRIDINE COMPOUNDS FOR USE IN THERAPY ELARA PHARMACEUTICALS GMBH (DE) 2012-10-04 — — WO claimed
US-20140221354-A1 IMIDAZO [1,2-a]PYRIDINE COMPOUNDS FOR USE IN THERAPY EMBLEM TECHNOLOGY TRANSFER GMBH (DE) 2014-08-07 — — US disclosed
EP-2691392-A1 IMIDAZO [1,2-A]PYRIDINE COMPOUNDS FOR USE IN THERAPY EMBLEM Technology Transfer GmbH (DE) 2014-02-05 — — EP disclosed
WO-2012130322-A1 IMIDAZO [1,2-A]PYRIDINE COMPOUNDS FOR USE IN THERAPY ELARA PHARMACEUTICALS GMBH (DE) 2012-10-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140221354-A1 IMIDAZO [1,2-a]PYRIDINE COMPOUNDS FOR USE IN THERAPY HIF1A, HIF1AN, EGLN3 SLC2A1 1235/4885KCNK3 2267/4885KCNK9 4476/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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