SCHEMBL12818894

SCHEMBL12818894

COc1ccc(-c2nc3ccc(-c4ccc(C#N)c(C)c4)cn3c2CN2CCCNCC2)cc1

nearest known ligand 0.51

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ SLC2A1 P11166 18/20 0.51
▸ KCNK3 O14649 1/20 0.42
▸ KCNK9 Q9NPC2 1/20 0.42
▸ SLC2A2 P11168 1/20 0.41
▸ MEN1 O00255 1/20 0.41
▸ KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12819664 0.92 SLC2A1 (0.52) SLC2A1KCNK3KCNK9SLC2A2MEN1
SCHEMBL12819326 0.90 SLC2A1 (0.62) SLC2A1SLC2A2MEN1KMT2A
SCHEMBL12819112 0.90 SLC2A1 (0.56) SLC2A1MEN1KMT2A
SCHEMBL12819118 0.88 SLC2A1 (0.58) SLC2A1KCNK3KCNK9MEN1KMT2A
SCHEMBL12819105 0.88 SLC2A1 (0.58) SLC2A1KCNK3KCNK9MEN1KMT2A
SCHEMBL12819049 0.88 SLC2A1 (0.52) SLC2A1KCNK3KCNK9
SCHEMBL12819373 0.87 SLC2A1 (0.66) SLC2A1MEN1KMT2A
SCHEMBL12818941 0.85 SLC2A1 (0.51) SLC2A1KCNK3KCNK9MEN1KMT2A
SCHEMBL12819123 0.85 SLC2A1 (0.61) SLC2A1MEN1KMT2A
SCHEMBL12819345 0.85 SLC2A1 (0.59) SLC2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140221354-A1 IMIDAZO [1,2-a]PYRIDINE COMPOUNDS FOR USE IN THERAPY EMBLEM TECHNOLOGY TRANSFER GMBH (DE) 2014-08-07 — — US claimed
US-20140221354-A1 IMIDAZO [1,2-a]PYRIDINE COMPOUNDS FOR USE IN THERAPY EMBLEM TECHNOLOGY TRANSFER GMBH (DE) 2014-08-07 — — US disclosed
EP-2691392-A1 IMIDAZO [1,2-A]PYRIDINE COMPOUNDS FOR USE IN THERAPY EMBLEM Technology Transfer GmbH (DE) 2014-02-05 — — EP disclosed
WO-2012130322-A1 IMIDAZO [1,2-A]PYRIDINE COMPOUNDS FOR USE IN THERAPY ELARA PHARMACEUTICALS GMBH (DE) 2012-10-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140221354-A1 IMIDAZO [1,2-a]PYRIDINE COMPOUNDS FOR USE IN THERAPY HIF1A, HIF1AN, EGLN3 SLC2A1 1235/4885KCNK3 2267/4885KCNK9 4476/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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