SCHEMBL12819040

SCHEMBL12819040

Cc1ccc(-c2ccc3nc(-c4ccc(C#N)s4)c(CN4CCN(C)CC4)n3c2)cc1

nearest known ligand 0.53

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ SLC2A1 P11166 17/20 0.53
▸ SMN1; SMN2 Q16637 1/20 0.42
▸ KDM4E B2RXH2 1/20 0.40
▸ ALDH1A1 P00352 1/20 0.40
▸ HTT P42858 1/20 0.40
▸ NPSR1 Q6W5P4 1/20 0.40
▸ SLC2A3 P11169 1/20 0.39
▸ SLC2A4 P14672 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12819019 0.93 SLC2A1 (0.53) SLC2A1SMN1; SMN2KDM4EALDH1A1HTT
SCHEMBL12818650 0.89 SLC2A1 (0.59) SLC2A1
SCHEMBL12819195 0.84 SLC2A1 (0.55) SLC2A1SMN1; SMN2KDM4EALDH1A1HTT
SCHEMBL12818250 0.82 SLC2A1 (0.55) SLC2A1SMN1; SMN2KDM4EALDH1A1HTT
SCHEMBL12818614 0.82 SLC2A1 (0.50) SLC2A1KDM4EHTT
SCHEMBL12818859 0.81 SLC2A1 (0.61) SLC2A1KDM4EHTTSLC2A3SLC2A4
SCHEMBL12818437 0.80 SLC2A1 (0.56) SLC2A1SMN1; SMN2KDM4EALDH1A1HTT
SCHEMBL12818892 0.80 SLC2A1 (0.59) SLC2A1SMN1; SMN2KDM4EALDH1A1HTT
SCHEMBL12819173 0.80 SLC2A1 (0.50) SLC2A1KDM4EALDH1A1HTTNPSR1
SCHEMBL12818943 0.79 SLC2A1 (0.60) SLC2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140221354-A1 IMIDAZO [1,2-a]PYRIDINE COMPOUNDS FOR USE IN THERAPY EMBLEM TECHNOLOGY TRANSFER GMBH (DE) 2014-08-07 — — US claimed
EP-2691392-A1 IMIDAZO [1,2-A]PYRIDINE COMPOUNDS FOR USE IN THERAPY EMBLEM Technology Transfer GmbH (DE) 2014-02-05 — — EP claimed
WO-2012130322-A1 IMIDAZO [1,2-A]PYRIDINE COMPOUNDS FOR USE IN THERAPY ELARA PHARMACEUTICALS GMBH (DE) 2012-10-04 — — WO claimed
US-20140221354-A1 IMIDAZO [1,2-a]PYRIDINE COMPOUNDS FOR USE IN THERAPY EMBLEM TECHNOLOGY TRANSFER GMBH (DE) 2014-08-07 — — US disclosed
EP-2691392-A1 IMIDAZO [1,2-A]PYRIDINE COMPOUNDS FOR USE IN THERAPY EMBLEM Technology Transfer GmbH (DE) 2014-02-05 — — EP disclosed
WO-2012130322-A1 IMIDAZO [1,2-A]PYRIDINE COMPOUNDS FOR USE IN THERAPY ELARA PHARMACEUTICALS GMBH (DE) 2012-10-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140221354-A1 IMIDAZO [1,2-a]PYRIDINE COMPOUNDS FOR USE IN THERAPY HIF1A, HIF1AN, EGLN3 SLC2A1 1235/4885SMN1; SMN2 3227/4885KDM4E 658/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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