Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.68 |
| ▸ | PDE1A | P54750 | 7/20 | 0.68 |
| ▸ | PDE1B | Q01064 | 7/20 | 0.68 |
| ▸ | PDE1C | Q14123 | 7/20 | 0.68 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.57 |
| ▸ | PDE6A | P16499 | 2/20 | 0.57 |
| ▸ | PDE2A | O00408 | 1/20 | 0.57 |
| ▸ | PDE6D | O43924 | 1/20 | 0.57 |
| ▸ | PDE9A | O76083 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | PDE6G | P18545 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | PDE6B | P35913 | 1/20 | 0.57 |
| ▸ | PDE6C | P51160 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12823411 | 0.92 | PDE5A (0.78) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL12822810 | 0.91 | PDE5A (0.81) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL973867 | 0.89 | PDE5A (0.85) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL12823019 | 0.87 | PDE5A (0.74) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL12823518 | 0.85 | PDE5A (0.69) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL13848 | 0.84 | PDE5A (0.78) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL12824026 | 0.83 | PDE5A (0.70) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL13579 | 0.83 | PDE5A (0.79) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL8251760 | 0.83 | PDE5A (0.78) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL12823740 | 0.82 | PDE5A (0.78) | PDE5APDE1APDE1BPDE1CPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295436-A1 | 2-Phenyl-subsitituted Imidazotriazinones as Phosphodiesterase V inhibitors | Bayer Schering Pharma AG (DE) | 2011-03-16 | — | — | EP | disclosed |