Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 10/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.49 |
| ▸ | MYLK4 | Q86YV6 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 2/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12825406 | 0.94 | TTK (0.66) | TTKROCK2PLK4CHEK2AURKB | |
| SCHEMBL12826114 | 0.93 | TTK (0.60) | TTKROCK2ROCK1MYLK4MAPK1 | |
| SCHEMBL12825317 | 0.93 | TTK (0.57) | TTKROCK2ROCK1MYLK4MAPK1 | |
| SCHEMBL12826071 | 0.91 | TTK (0.56) | TTKROCK2ROCK1MYLK4MAPK1 | |
| SCHEMBL12825326 | 0.90 | TTK (0.54) | TTKROCK2ROCK1MYLK4MAPK1 | |
| SCHEMBL12825315 | 0.90 | TTK (0.56) | TTKROCK2ROCK1MYLK4MAPK1 | |
| SCHEMBL12825512 | 0.89 | TTK (0.63) | TTKROCK2PLK4CHEK2AURKB | |
| SCHEMBL12826113 | 0.89 | TTK (0.62) | TTKROCK2PLK4CHEK2AURKB | |
| SCHEMBL12826074 | 0.88 | TTK (0.53) | TTKROCK2ROCK1MYLK4MAPK1 | |
| SCHEMBL12826062 | 0.88 | AURKB (0.64) | TTKROCK2ROCK1MAPK1PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295413-A1 | Indazole compounds useful as protein kinase inhibitors | Vertex Pharmaceuticals Incorporated (US) | 2011-03-16 | — | — | EP | disclosed |