Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1457802 | 0.91 | PDE10A (0.73) | PDE10ASMN1; SMN2ALDH1A1MAPK1HPGD | |
| SCHEMBL6889025 | 0.91 | PDE10A (0.81) | PDE10ASMN1; SMN2ALDH1A1MAPK1HPGD | |
| SCHEMBL1458265 | 0.90 | PDE10A (0.72) | PDE10ASMN1; SMN2ALDH1A1MAPK1HPGD | |
| SCHEMBL6889411 | 0.90 | PDE10A (0.80) | PDE10ASMN1; SMN2ALDH1A1MAPK1HPGD | |
| SCHEMBL1458526 | 0.90 | PDE10A (0.82) | PDE10ASMN1; SMN2ALDH1A1MAPK1HPGD | |
| SCHEMBL1458378 | 0.90 | PDE10A (0.71) | PDE10ASMN1; SMN2ALDH1A1MAPK1HPGD | |
| SCHEMBL1458407 | 0.90 | PDE10A (0.71) | PDE10ASMN1; SMN2ALDH1A1MAPK1HPGD | |
| SCHEMBL1457776 | 0.90 | PDE10A (0.71) | PDE10ASMN1; SMN2ALDH1A1MAPK1HPGD | |
| SCHEMBL1458278 | 0.90 | PDE10A (0.71) | PDE10ASMN1; SMN2ALDH1A1MAPK1HPGD | |
| SCHEMBL6888553 | 0.89 | PDE10A (0.78) | PDE10ASMN1; SMN2ALDH1A1MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011036127-A1 | IMIDAZOPYRIDINE OR IMIDAZOPYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10A INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-31 | — | — | WO | disclosed |