Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 18/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.60 |
| ▸ | AXL | P30530 | 1/20 | 0.54 |
| ▸ | MERTK | Q12866 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12065527 | 0.83 | LRRK2 (0.81) | LRRK2 | |
| SCHEMBL12065526 | 0.80 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL12065542 | 0.80 | LRRK2 (0.77) | LRRK2 | |
| SCHEMBL7456753 | 0.80 | LRRK2 (0.77) | LRRK2AURKAAURKB | |
| SCHEMBL12065535 | 0.80 | LRRK2 (0.77) | LRRK2 | |
| SCHEMBL30680110 | 0.80 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL14615039 | 0.78 | LRRK2 (0.83) | LRRK2 | |
| SCHEMBL21855436 | 0.78 | LRRK2 (0.76) | LRRK2 | |
| SCHEMBL30680146 | 0.78 | LRRK2 (0.76) | LRRK2 | |
| SCHEMBL1466652 | 0.76 | LRRK2 (0.59) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011036566-A1 | METHODS FOR PREPARING PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-03-31 | — | — | WO | disclosed |