Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 14/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 14/20 | 0.36 |
| ▸ | CDK2 | P24941 | 14/20 | 0.36 |
| ▸ | CDK4 | P11802 | 5/20 | 0.36 |
| ▸ | CCND1 | P24385 | 5/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.36 |
| ▸ | CDK1 | P06493 | 3/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1241559 | 0.93 | CDK2 (0.36) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL2657518 | 0.93 | CDK2 (0.36) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL12204123 | 0.93 | CDK2 (0.36) | PPARGPPARDPPARACCNE2CCNE1 | |
| SCHEMBL12828467 | 0.92 | CDK2 (0.38) | PPARGPPARDPPARACCNE2CCNE1 | |
| SCHEMBL12828483 | 0.91 | CCNE2 (0.36) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL12828723 | 0.90 | CCNE1 (0.44) | PPARGPPARDPPARACCNE2CCNE1 | |
| SCHEMBL2656357 | 0.86 | CDK2 (0.36) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL1241874 | 0.86 | CDK2 (0.36) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL1241399 | 0.85 | CDK2 (0.38) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL2657006 | 0.85 | CDK2 (0.38) | CCNE2CCNE1CDK2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110077234-A1 | Urea Glucokinase Activators | NOVO NORDISK A/S (DK) | 2011-03-31 | — | — | US | disclosed |
| US-7884210-B2 | {2-[3-(2-Cyclohex-1-enyl-ethyl)-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid; for treatment of type 2 diabetes | NOVO NORDISK A/S (DK) | 2011-02-08 | — | — | US | disclosed |
| US-20090105482-A1 | Urea Glucokinase Activators | NOVO NORDISK A/S (DK) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105482-A1 | Urea Glucokinase Activators | GCK, GCKR, HK2 | PPARG 844/4885PPARD 1805/4885PPARA 2109/4885 |
| US-20110077234-A1 | Urea Glucokinase Activators | GCK, GCKR, HK2 | PPARG 844/4885PPARD 1805/4885PPARA 2109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.