Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.56 |
| ▸ | GSK3A | P49840 | 5/20 | 0.49 |
| ▸ | PIM1 | P11309 | 3/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11923949 | 0.91 | CHEK1 (0.69) | CHEK1PIM1PIM3PIM2GSK3B | |
| SCHEMBL11923953 | 0.88 | PIM2 (0.57) | PIM1PIM3PIM2GSK3B | |
| SCHEMBL11923952 | 0.88 | PIM2 (0.57) | PIM1PIM3PIM2GSK3B | |
| SCHEMBL16519545 | 0.81 | CHEK1 (0.84) | CHEK1GSK3APIM1PIM3PIM2 | |
| SCHEMBL11923950 | 0.79 | CHEK1 (0.46) | CHEK1PIM1PIM3PIM2GSK3B | |
| SCHEMBL11923948 | 0.79 | CHEK1 (0.46) | CHEK1PIM1PIM3PIM2GSK3B | |
| SCHEMBL11924235 | 0.74 | CHEK1 (0.73) | CHEK1PIM1PIM3PIM2GSK3B | |
| SCHEMBL11923929 | 0.72 | PIM1 (0.53) | CHEK1GSK3APIM1PIM3PIM2 | |
| SCHEMBL13155036 | 0.72 | CHEK1 (1.00) | CHEK1MAPK1 | |
| SCHEMBL13323032 | 0.72 | CHEK1 (0.81) | CHEK1GSK3APIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011025706-A2 | HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2011-03-03 | — | — | WO | disclosed |