Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.43 |
| ▸ | GRK5 | P34947 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.39 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 4/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9918545 | 0.88 | CSF1R (0.46) | LRRK2MAPTCSF1R | |
| SCHEMBL12833305 | 0.85 | NOTUM (0.40) | MAPTTTBK1TTBK2SYK | |
| SCHEMBL9918529 | 0.76 | JAK1 (0.34) | TTBK1TTBK2SYKRET | |
| SCHEMBL9921764 | 0.76 | MEN1 (0.40) | MAPTSYKCSF1R | |
| SCHEMBL9918539 | 0.76 | CSF1R (0.36) | LRRK2GRK5MAPTTTBK1TTBK2 | |
| SCHEMBL9918522 | 0.75 | CSF1R (0.38) | TTBK1TTBK2CSF1R | |
| SCHEMBL9918540 | 0.74 | EGFR (0.42) | GRK5CSF1RKCNH2 | |
| SCHEMBL12832928 | 0.73 | LRRK2 (0.45) | LRRK2 | |
| SCHEMBL9918558 | 0.72 | HTT (0.41) | LRRK2MAPT | |
| SCHEMBL9921982 | 0.72 | KDM4E (0.44) | LRRK2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011031554-A2 | HETEROCYCLIC COMPOUNDS AS JANUS KINASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2011-03-17 | — | — | WO | disclosed |