Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 5/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TET3 | O43151 | 1/20 | 0.40 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.40 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12834456 | 0.94 | NAMPT (0.46) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL12834471 | 0.93 | NAMPT (0.46) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL12833838 | 0.93 | NAMPT (0.45) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL12833908 | 0.93 | NAMPT (0.44) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL12833759 | 0.92 | NAMPT (0.49) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL12833806 | 0.92 | NAMPT (0.44) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL12834257 | 0.92 | NAMPT (0.44) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL14091103 | 0.92 | PDE10A (0.48) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL14090839 | 0.90 | NAMPT (0.48) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL12834155 | 0.90 | NAMPT (0.43) | HDAC6HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298770-A1 | Heterocyclic compounds as TrkA modulators | ChemBridge Corporation (US) | 2011-03-23 | — | — | EP | disclosed |