Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.56 |
| ▸ | HPSE | Q9Y251 | 10/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12833934 | 0.94 | ADORA2A (0.48) | ADORA2AHPSEMAPTHDAC3HDAC1 | |
| SCHEMBL12834486 | 0.93 | HPSE (0.48) | ADORA2AHPSEMAPTSMN1; SMN2HDAC3 | |
| SCHEMBL12834282 | 0.93 | HPSE (0.48) | ADORA2AHPSEMAPTSMN1; SMN2POLB | |
| SCHEMBL12833884 | 0.93 | HPSE (0.48) | ADORA2AHPSEMAPTSMN1; SMN2POLB | |
| SCHEMBL12833725 | 0.93 | HPSE (0.48) | ADORA2AHPSESMN1; SMN2POLBHDAC3 | |
| SCHEMBL12833800 | 0.93 | HPSE (0.49) | ADORA2AHPSEHDAC3HDAC1HDAC2 | |
| SCHEMBL14531461 | 0.92 | ADORA2A (0.51) | ADORA2AHPSEMAPTSMN1; SMN2LMNA | |
| SCHEMBL12834169 | 0.91 | HPSE (0.48) | ADORA2AHPSEHDAC3HDAC1HDAC2 | |
| SCHEMBL12834217 | 0.90 | HPSE (0.48) | ADORA2AHPSESMN1; SMN2POLBHDAC3 | |
| SCHEMBL14090897 | 0.90 | HPSE (0.46) | ADORA2AHPSEMAPTHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298770-A1 | Heterocyclic compounds as TrkA modulators | ChemBridge Corporation (US) | 2011-03-23 | — | — | EP | disclosed |