Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 20/20 | 0.76 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13286608 | 1.00 | TLR4 (0.76) | TLR4LY96 | |
| SCHEMBL13302898 | 1.00 | TLR4 (0.76) | TLR4LY96 | |
| SCHEMBL13233352 | 0.95 | TLR4 (0.78) | TLR4LY96 | |
| SCHEMBL13325121 | 0.91 | TLR4 (0.65) | TLR4LY96 | |
| SCHEMBL12836291 | 0.91 | TLR4 (0.65) | TLR4LY96 | |
| SCHEMBL13803955 | 0.91 | TLR4 (0.65) | TLR4LY96 | |
| SCHEMBL12601161 | 0.91 | TLR4 (0.65) | TLR4LY96 | |
| SCHEMBL10042134 | 0.90 | TLR4 (0.63) | TLR4LY96 | |
| SCHEMBL10042131 | 0.89 | TLR4 (0.61) | TLR4LY96 | |
| SCHEMBL14136535 | 0.88 | TLR4 (0.70) | TLR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906633-B2 | Reagents and methods for preparing LPS antagonist B1287 and stereoisomers thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-03-15 | — | — | US | disclosed |