Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 11/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TLR4 | O00206 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1516487 | 0.88 | MAP2K1 (0.55) | BRAFMAP2K1TSHR | |
| SCHEMBL1516512 | 0.88 | BRAF (0.48) | BRAFMAP2K1 | |
| SCHEMBL18086455 | 0.78 | BRAF (0.48) | BRAFMAP2K1BRD4TSHRHSD17B10 | |
| SCHEMBL9284438 | 0.78 | BRAF (0.48) | BRAFMAP2K1BRD4 | |
| SCHEMBL1516484 | 0.78 | MAP2K1 (0.58) | BRAFMAP2K1TSHR | |
| SCHEMBL1516527 | 0.78 | MAP2K1 (0.45) | BRAFMAP2K1 | |
| SCHEMBL720442 | 0.77 | MAP2K1 (0.51) | BRAFMAP2K1 | |
| SCHEMBL13113284 | 0.75 | BRAF (0.34) | BRAFMAP2K1BRD4 | |
| SCHEMBL14549221 | 0.75 | MAP2K1 (0.59) | MAP2K1 | |
| SCHEMBL14549220 | 0.74 | MAP2K1 (0.60) | MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897624-B2 | Pyridone sulfonamides and pyridone sulfamides as MEK inhibitors | ARDEA BIOSCIENCES (US) | 2011-03-01 | — | — | US | disclosed |
| WO-2009018238-A1 | COMBINATIONS OF MEK INHIBITORS AND RAF KINASE INHIBITORS AND USES THEREOF | ARDEA BIOSCIENCES, INC. (US) | 2009-02-05 | — | — | WO | disclosed |