Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
| ▸ | HSPA5 | P11021 | 3/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 8/20 | 0.35 |
| ▸ | CDC25B | P30305 | 8/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.32 |
| ▸ | PTPN6 | P29350 | 4/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.32 |
| ▸ | GJB2 | P29033 | 1/20 | 0.31 |
| ▸ | ATG7 | O95352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13667763 | 0.87 | PTPN1 (0.38) | PDE2AHSPA5PTPN1CDC25BHTR1A | |
| SCHEMBL12243227 | 0.83 | PDE2A (0.37) | PDE2AHSPA5PTPN1CDC25BHTR1A | |
| SCHEMBL13667496 | 0.83 | PTPN1 (0.34) | PDE2AHSPA5PTPN1CDC25BHTR1A | |
| SCHEMBL12835936 | 0.82 | PTPN1 (0.35) | PDE2AHSPA5PTPN1CDC25BHTR1A | |
| SCHEMBL12243232 | 0.80 | HSPA5 (0.35) | PDE2AHSPA5BCHE | |
| SCHEMBL19997429 | 0.80 | HSPA5 (0.35) | PDE2AHSPA5BCHE | |
| SCHEMBL2374198 | 0.80 | HSPA5 (0.35) | PDE2AHSPA5BCHE | |
| SCHEMBL24539016 | 0.79 | PDE2A (0.38) | PDE2AHSPA5PTPN1CDC25BHTR1A | |
| SCHEMBL18490453 | 0.79 | PDE2A (0.38) | PDE2AHSPA5PTPN1CDC25BHTR1A | |
| SCHEMBL20434838 | 0.79 | PDE2A (0.38) | PDE2AHSPA5PTPN1CDC25BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011035250-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 1'-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS | GILEAD SCIENCES, INC. (US) | 2011-03-24 | — | — | WO | disclosed |