Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 18/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12836696 | 0.90 | PIK3CA (0.55) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL12836659 | 0.88 | PIK3CA (0.51) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1484567 | 0.86 | PIK3CA (0.53) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1484555 | 0.80 | PIK3CA (0.63) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1484793 | 0.80 | PIK3CA (0.62) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL12340460 | 0.77 | PIK3CA (0.52) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1484836 | 0.76 | PIK3CA (0.81) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1485115 | 0.75 | PIK3CA (0.58) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1484688 | 0.75 | PIK3CA (0.53) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| Hydrochloric Acid SCHEMBL1485112 | 0.75 | PIK3CA (0.57) | PIK3CAPIK3CBPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011036284-A1 | BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-31 | — | — | WO | disclosed |