Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.60 |
| ▸ | PLK1 | P53350 | 18/20 | 0.40 |
| ▸ | PLK3 | Q9H4B4 | 12/20 | 0.40 |
| ▸ | PLK2 | Q9NYY3 | 12/20 | 0.40 |
| ▸ | TAF1 | P21675 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2360486 | 0.92 | BRD4 (0.59) | BRD4PLK1PLK3PLK2TAF1 | |
| SCHEMBL523873 | 0.92 | BRD4 (0.59) | BRD4PLK1PLK3PLK2TAF1 | |
| SCHEMBL20815326 | 0.92 | BRD4 (0.59) | BRD4PLK1PLK3PLK2TAF1 | |
| SCHEMBL523874 | 0.92 | BRD4 (0.59) | BRD4PLK1PLK3PLK2TAF1 | |
| SCHEMBL10313789 | 0.92 | BRD4 (0.59) | BRD4PLK1PLK3PLK2TAF1 | |
| SCHEMBL523203 | 0.92 | BRD4 (0.66) | BRD4PLK1PLK3PLK2 | |
| SCHEMBL524306 | 0.92 | BRD4 (0.66) | BRD4PLK1PLK3PLK2 | |
| SCHEMBL524305 | 0.92 | BRD4 (0.66) | BRD4PLK1PLK3PLK2 | |
| SCHEMBL20815288 | 0.88 | BRD4 (0.55) | BRD4PLK1PLK3PLK2TAF1 | |
| SCHEMBL524048 | 0.88 | BRD4 (0.55) | BRD4PLK1PLK3PLK2TAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011038185-A2 | METHODS FOR PREPARING PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-03-31 | — | — | WO | disclosed |