Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.74 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.74 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.74 |
| ▸ | RET | P07949 | 3/20 | 0.74 |
| ▸ | KIT | P10721 | 3/20 | 0.74 |
| ▸ | SRC | P12931 | 3/20 | 0.74 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.74 |
| ▸ | BRAF | P15056 | 2/20 | 0.74 |
| ▸ | CIT | O14578 | 2/20 | 0.74 |
| ▸ | GAK | O14976 | 2/20 | 0.74 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.74 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.74 |
| ▸ | STK17B | O94768 | 2/20 | 0.74 |
| ▸ | STK10 | O94804 | 2/20 | 0.74 |
| ▸ | ABL1 | P00519 | 2/20 | 0.74 |
| ▸ | LCK | P06239 | 2/20 | 0.74 |
| ▸ | LYN | P07948 | 2/20 | 0.74 |
| ▸ | MET | P08581 | 2/20 | 0.74 |
| ▸ | HCK | P08631 | 2/20 | 0.74 |
| ▸ | FGR | P09769 | 2/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1446406 | 0.96 | EGFR (0.76) | EGFRERBB2ERBB4RETKIT | |
| SCHEMBL12743118 | 0.96 | EGFR (0.76) | EGFRERBB2ERBB4RETKIT | |
| SCHEMBL1446409 | 0.96 | EGFR (0.76) | EGFRERBB2ERBB4RETKIT | |
| SCHEMBL1446351 | 0.93 | EGFR (0.73) | EGFRERBB2ERBB4RETKIT | |
| SCHEMBL1446353 | 0.93 | EGFR (0.73) | EGFRERBB2ERBB4RETKIT | |
| SCHEMBL12743048 | 0.92 | EGFR (0.75) | EGFRERBB2ERBB4RETKIT | |
| SCHEMBL1446512 | 0.92 | EGFR (0.76) | EGFRERBB2ERBB4RETKIT | |
| SCHEMBL1446516 | 0.92 | EGFR (0.76) | EGFRERBB2ERBB4RETKIT | |
| SCHEMBL1446583 | 0.92 | EGFR (0.80) | EGFRERBB2ERBB4RETKIT | |
| SCHEMBL1446147 | 0.90 | EGFR (0.76) | EGFRERBB2ERBB4RETKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343982-B2 | Bicyclic heterocyclic compounds pharmaceutical compositions containing these compounds, their use and process for preparing the same | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2013-01-01 | — | — | US | disclosed |
| US-8343982-B2 | Bicyclic heterocyclic compounds pharmaceutical compositions containing these compounds, their use and process for preparing the same | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2013-01-01 | — | — | US | disclosed |
| EP-2298305-A1 | 4-(N-Phenylamino)-quinazolines/quinolines as inhibitors of tyrosine kinases | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2011-03-23 | — | — | EP | disclosed |