Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.68 |
| ▸ | KDR | P35968 | 2/20 | 0.59 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.59 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | INSR | P06213 | 1/20 | 0.59 |
| ▸ | FBP1 | P09467 | 1/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.59 |
| ▸ | FLT4 | P35916 | 1/20 | 0.59 |
| ▸ | CLK1 | P49759 | 1/20 | 0.59 |
| ▸ | TEK | Q02763 | 1/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1446721 | 1.00 | EGFR (0.70) | EGFRERBB2KDREPHB4EPHA2 | |
| SCHEMBL1446466 | 1.00 | EGFR (0.70) | EGFRERBB2KDREPHB4EPHA2 | |
| SCHEMBL15400466 | 0.90 | EGFR (0.67) | EGFRERBB2KDREPHB4EPHA2 | |
| SCHEMBL1447316 | 0.88 | EGFR (0.72) | EGFRERBB2KDREPHB4AURKA | |
| SCHEMBL4466661 | 0.88 | ERBB2 (0.71) | EGFRERBB2 | |
| SCHEMBL4883905 | 0.87 | ERBB2 (0.82) | EGFRERBB2KDREPHB4AURKA | |
| SCHEMBL1447161 | 0.87 | EGFR (0.78) | EGFRERBB2KDREPHB4EPHA2 | |
| SCHEMBL14489874 | 0.87 | EGFR (0.80) | EGFRERBB2KDREPHB4EPHA2 | |
| SCHEMBL1333601 | 0.87 | EGFR (0.80) | EGFRERBB2KDREPHB4EPHA2 | |
| SCHEMBL185479 | 0.87 | EGFR (0.74) | EGFRERBB2KDREPHB4EPHA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298305-A1 | 4-(N-Phenylamino)-quinazolines/quinolines as inhibitors of tyrosine kinases | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2011-03-23 | — | — | EP | disclosed |