SCHEMBL12839353

SCHEMBL12839353

O=C(CCc1ccccc1)Nc1nc2c(nc1-c1ccc(O)cc1)-c1ccccc1CC2

nearest known ligand 0.46

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 12/20 0.46
TOP2A P11388 1/20 0.43
TOP2B Q02880 1/20 0.43
MAPK14 Q16539 1/20 0.43
PLTP P55058 1/20 0.42
LMNA P02545 1/20 0.41
CYP2C8 P10632 2/20 0.40
CYP2C9 P11712 2/20 0.40
TRPV1 Q8NER1 1/20 0.40
KMT2A Q03164 1/20 0.39
MAPT P10636 1/20 0.39
HTT P42858 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12839329 0.94 TRPV1 (0.48) HCAR2TOP2ATOP2BMAPK14PLTP
SCHEMBL12839298 0.94 MAPK14 (0.45) HCAR2MAPK14LMNAKMT2AMAPT
SCHEMBL12840580 0.92 HCAR2 (0.48) HCAR2TOP2ATOP2BMAPK14PLTP
SCHEMBL12839338 0.90 MAPK14 (0.41) MAPK14KMT2A
SCHEMBL13068114 0.89 HCAR2 (0.49) HCAR2TOP2ATOP2BMAPK14LMNA
SCHEMBL12840708 0.89 HCAR2 (0.42) HCAR2TOP2ATOP2BMAPK14PLTP
SCHEMBL12838677 0.89 POLB (0.45) HCAR2TOP2ATOP2BMAPK14PLTP
SCHEMBL12839299 0.88 HDAC1 (0.44) MAPK14TRPV1KMT2A
SCHEMBL12839103 0.87 CCNE1 (0.41) MAPK14KMT2AMAPTHTT
SCHEMBL12840558 0.87 TRPV1 (0.47) HCAR2TOP2ATOP2BPLTPCYP2C8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110070656-A1 Fluorescent Proteins JNC CORPORATION (JP) 2011-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110070656-A1 Fluorescent Proteins CACYBP, CHLSN, LCP2 HCAR2 3839/4885TOP2A 3075/4885TOP2B 2921/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.