SCHEMBL128400

SCHEMBL128400

CCCCCCC#C[NH]

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL130463 1.00 PTPN7 (0.46)
SCHEMBL129928 1.00 PTPN7 (0.46)
SCHEMBL132676 1.00 PTPN7 (0.46)
SCHEMBL128486 1.00 PTPN7 (0.46)
SCHEMBL128739 1.00 PTPN7 (0.46)
SCHEMBL131775 1.00 PTPN7 (0.46)
SCHEMBL130444 1.00 PTPN7 (0.46)
SCHEMBL131483 0.97
SCHEMBL127557 0.88
SCHEMBL11071831 0.85 PTPN7 (0.58)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1756271-B1 METHODS FOR OBTAINING OPTICALLY ACTIVE EPOXIDES AND VICINAL DIOLS FROM 2,2-DISUBSTITUTED EPOXIDES CSIR (ZA) 2015-12-09 EP disclosed
EP-1753862-B1 METHODS FOR OBTAINING OPTICALLY ACTIVE EPOXIDES AND VICINAL DIOLS FROM MESO-EPOXIDES CSIR (ZA) 2015-11-18 EP disclosed
EP-1512397-B1 O-SUBSTITUTED HYDROXYARYL DERIVATIVES INST MED MOLECULAR DESIGN INC (JP) 2014-10-08 EP disclosed
EP-1944290-B1 NOVEL 1-2-DIHYDROQUINOLINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY SANTEN PHARMACEUTICAL CO LTD (JP) 2013-12-04 EP disclosed
US-8420635-B2 Method for preventing or treating a glucocorticoid receptor-related disease SANTEN PHARMACEUTICAL CO., LTD. (JP) 2013-04-16 US disclosed
US-8263657-B2 Blocking neurokinins; using a benzene compound containing hydroxy or acetoxy group; antiinflammatory agents INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) 2012-09-11 US disclosed
EP-1844766-B1 Inhibitors against the production and release of inflammatory cytokines INST MED MOLECULAR DESIGN INC (JP) 2012-04-18 EP disclosed
EP-1352650-B1 INHIBITORS AGAINST THE PRODUCTION AND RELEASE OF INFLAMMATORY CYTOKINES INST MED MOLECULAR DESIGN INC (JP) 2012-03-07 EP disclosed
US-8097759-B2 Inflammatory cytokine release inhibitor INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) 2012-01-17 US disclosed
US-20110263589-A1 Method for preventing or treating a glucocorticoid receptor-related disease SANTEN PHARMACEUTICAL CO., LTD. (JP) 2011-10-27 US disclosed
EP-0253665-B1 SILVER HALIDE PHOTOGRAPHIC LIGHTSENSITIVE SYSTEMS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1992-01-02 EP disclosed
US-4925832-A HYDRAZIDE DERIVATIVE MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1990-05-15 US disclosed
US-4798780-A CONTRAST MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1989-01-17 US disclosed
EP-0253665-A2 Silver halide photographic lightsensitive systems MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1988-01-20 EP disclosed
US-4377634-A SENSITIZATION OF SILVER HALIDE EMULSIONS USING AN ARYL HYDRAZIDE AND A HYDROQUIONE; NEGATIVES FUJI PHOTO FILM CO., LTD. (JP) 1983-03-22 US disclosed
US-4272606-A HYDRAZIDE, THIOAMIDE FUJI PHOTO FILM CO., LTD. (JP) 1981-06-09 US disclosed
US-4224401-A Silver halide photographic emulsions and image forming process FUJI PHOTO FILM CO., LTD. (JP) 1980-09-23 US disclosed
US-4221857-A DEVELOPER COMPRISING SULFITE ION, A DIHYDROXYBENZENE, AND A HYDRAZIDE COMPOUND FUJI PHOTO FILM CO., LTD. (JP) 1980-09-09 US disclosed
US-4168977-A CONTAINING HYDRAZIDES, NEGATIVES FUJI PHOTO FILM CO., LTD. (JP) 1979-09-25 US disclosed
US-4166742-A ANTIFOGGING AGENTS FUJI PHOTO FILM CO., LTD. (JP) 1979-09-04 US disclosed