Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.81 |
| ▸ | CDK8 | P49336 | 3/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.67 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.63 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.63 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | CCNC | P24863 | 1/20 | 0.60 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1600309 | 0.86 | CDK8 (0.82) | JAK2CDK8MAPK14MAPK13MAPK12 | |
| SCHEMBL26936743 | 0.84 | CDK8 (0.66) | JAK2CDK8MAPK14MAPK13MAPK12 | |
| SCHEMBL9967321 | 0.84 | CDK8 (0.78) | JAK2CDK8MAPK14MAPK13MAPK12 | |
| SCHEMBL13199966 | 0.83 | MAPK14 (0.63) | JAK2CDK8MAPK14MAPK13MAPK12 | |
| SCHEMBL1600918 | 0.83 | MAPK14 (0.68) | JAK2CDK8MAPK14MAPK13MAPK12 | |
| SCHEMBL18744685 | 0.83 | CDK8 (0.76) | JAK2CDK8MAPK14MAPK13MAPK12 | |
| SCHEMBL15946922 | 0.83 | CDK8 (0.76) | JAK2CDK8MAPK14MAPK13MAPK12 | |
| SCHEMBL19303194 | 0.83 | CDK8 (1.00) | CDK8MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL1600736 | 0.82 | MAPK14 (0.64) | JAK2CDK8MAPK14MAPK13MAPK12 | |
| SCHEMBL1600182 | 0.82 | CDK8 (0.60) | JAK2CDK8MAPK14MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557797-B2 | Triazolopyridine derivatives and their therapeutic use | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-10-15 | — | — | US | disclosed |
| US-8557797-B2 | Triazolopyridine derivatives and their therapeutic use | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-10-15 | — | — | US | disclosed |
| US-8557797-B2 | Triazolopyridine derivatives and their therapeutic use | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-10-15 | — | — | US | disclosed |
| US-20120088763-A1 | TRIAZOLOPYRIDINE DERIVATIVES AND THEIR THERAPEUTIC USE | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-04-12 | — | — | US | disclosed |
| US-20120088763-A1 | TRIAZOLOPYRIDINE DERIVATIVES AND THEIR THERAPEUTIC USE | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-04-12 | — | — | US | disclosed |
| US-20120088763-A1 | TRIAZOLOPYRIDINE DERIVATIVES AND THEIR THERAPEUTIC USE | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-04-12 | — | — | US | disclosed |
| WO-2010094956-A1 | TRIAZOLOPYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | PULMAGEN THERAPEUTICS (INFLAMMATION) LIMITED. (GB) | 2010-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088763-A1 | TRIAZOLOPYRIDINE DERIVATIVES AND THEIR THERAPEUTIC USE | CNKSR1, MOK, MAPK1 | JAK2 46/4885CDK8 324/4885MAPK14 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.