Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.73 |
| ▸ | TEC | P42680 | 2/20 | 0.72 |
| ▸ | TXK | P42681 | 2/20 | 0.72 |
| ▸ | BMX | P51813 | 2/20 | 0.72 |
| ▸ | ITK | Q08881 | 2/20 | 0.72 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1531613 | 0.91 | BTK (0.74) | BTKTECTXKBMXITK | |
| SCHEMBL10206475 | 0.88 | BTK (0.76) | BTKTECTXKBMXITK | |
| SCHEMBL10207438 | 0.87 | BTK (0.75) | BTKTECTXKBMXITK | |
| SCHEMBL10206330 | 0.86 | BTK (0.74) | BTKTECTXKBMXITK | |
| SCHEMBL10206281 | 0.85 | BTK (0.83) | BTKTECTXKBMXITK | |
| SCHEMBL1531612 | 0.85 | BTK (0.85) | BTKTECTXKBMXITK | |
| SCHEMBL1531596 | 0.84 | BTK (0.74) | BTKTECTXKBMXITK | |
| SCHEMBL1531487 | 0.84 | BTK (0.74) | BTKTECTXKBMXITK | |
| SCHEMBL9929325 | 0.84 | BTK (1.00) | BTKTECTXKBMXITK | |
| SCHEMBL1531541 | 0.84 | BTK (1.00) | BTKTECTXKBMXITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011029043-A1 | HETEROARYL BTK INHIBITORS | BIOGEN IDEC MA INC. (US) | 2011-03-10 | — | — | WO | disclosed |