Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.80 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.80 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.80 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.80 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.80 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.78 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.78 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.78 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.78 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.78 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.78 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.78 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.78 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.78 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.78 |
| ▸ | MTOR | P42345 | 2/20 | 0.78 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.78 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.78 |
| ▸ | PRKDC | P78527 | 1/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1284306 | 0.93 | HDAC1 (0.81) | HDAC1HDAC2HDAC10HDAC11HDAC3 | |
| SCHEMBL1283944 | 0.93 | HDAC1 (0.81) | HDAC1HDAC2HDAC10HDAC11HDAC3 | |
| SCHEMBL15765696 | 0.92 | HDAC1 (0.77) | HDAC1HDAC2HDAC10HDAC11HDAC3 | |
| SCHEMBL1284407 | 0.92 | HDAC1 (0.80) | HDAC1HDAC2HDAC10HDAC11HDAC3 | |
| SCHEMBL1284118 | 0.92 | HDAC1 (0.80) | HDAC1HDAC2HDAC10HDAC11HDAC3 | |
| SCHEMBL1284516 | 0.92 | HDAC1 (0.80) | HDAC1HDAC2HDAC10HDAC11HDAC3 | |
| SCHEMBL1284391 | 0.92 | HDAC1 (0.80) | HDAC1HDAC2HDAC10HDAC11HDAC3 | |
| SCHEMBL1284354 | 0.92 | HDAC1 (0.79) | HDAC1HDAC2HDAC10HDAC11HDAC3 | |
| SCHEMBL1283996 | 0.92 | HDAC1 (0.76) | HDAC1HDAC2HDAC10HDAC11HDAC3 | |
| SCHEMBL1284265 | 0.92 | HDAC1 (0.78) | HDAC1HDAC2HDAC10HDAC11HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250230169-A1 | Phosphoinositide 3-Kinase Inhibitors with a Zinc Binding Moiety | CURIS INC (US) | 2025-07-17 | — | — | US | disclosed |
| US-20230227467-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS INC (US) | 2023-07-20 | — | — | US | disclosed |
| US-20230227467-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS INC (US) | 2023-07-20 | — | — | US | disclosed |
| US-20230227467-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS INC (US) | 2023-07-20 | — | — | US | disclosed |
| US-11597732-B2 | Phosphoinositide 3-kinase inhibitors with a zinc binding moiety | CURIS, INC. (US) | 2023-03-07 | — | — | US | disclosed |
| US-20220402934-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS INC (US) | 2022-12-22 | — | — | US | disclosed |
| US-20220402934-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS INC (US) | 2022-12-22 | — | — | US | disclosed |
| US-11261195-B2 | Phosphoinositide 3-kinase inhibitors with a zinc binding moiety | CURIS, INC. (US) | 2022-03-01 | — | — | US | disclosed |
| US-20210214370-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS INC (US) | 2021-07-15 | — | — | US | disclosed |
| US-20210214370-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS INC (US) | 2021-07-15 | — | — | US | disclosed |
| US-20120088764-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS, INC. | 2012-04-12 | — | — | US | disclosed |
| EP-2385832-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | Curis, Inc. (US) | 2011-11-16 | — | — | EP | disclosed |
| WO-2011130628-A1 | TREATMENT OF CANCERS HAVING K-RAS MUTATIONS | CURIS, INC. (US) | 2011-10-20 | — | — | WO | disclosed |
| WO-2011130628-A1 | TREATMENT OF CANCERS HAVING K-RAS MUTATIONS | CURIS, INC. (US) | 2011-10-20 | — | — | WO | disclosed |
| US-8040979-B2 | Generating a phase value for a complex signal | INFINEON TECHNOLOGIES AG (DE) | 2011-10-18 | — | — | US | disclosed |
| US-20100222343-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS, INC. | 2010-09-02 | — | — | US | disclosed |
| US-20100222343-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS, INC. | 2010-09-02 | — | — | US | disclosed |
| US-20100222343-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS, INC. | 2010-09-02 | — | — | US | disclosed |
| WO-2010080996-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS, INC. (US) | 2010-07-15 | — | — | WO | disclosed |
| WO-2010080996-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS, INC. (US) | 2010-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11261195-B2 | Phosphoinositide 3-kinase inhibitors with a zinc binding moiety | BAZ2A, BAZ2B, PI4KB | HDAC1 10/4885HDAC2 27/4885HDAC10 49/4885 |
| US-20210214370-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | BAZ2A, BAZ2B, PI4KB | HDAC1 10/4885HDAC2 27/4885HDAC10 49/4885 |
| US-11597732-B2 | Phosphoinositide 3-kinase inhibitors with a zinc binding moiety | BAZ2A, BAZ2B, PI4KB | HDAC1 10/4885HDAC2 27/4885HDAC10 49/4885 |
| US-20250230169-A1 | Phosphoinositide 3-Kinase Inhibitors with a Zinc Binding Moiety | BAZ2A, BAZ2B, PI4KB | HDAC1 10/4885HDAC2 27/4885HDAC10 49/4885 |
| US-20100222343-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | BAZ2A, BAZ2B, PI4KB | HDAC1 10/4885HDAC2 27/4885HDAC10 49/4885 |
| US-20120088764-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | BAZ2A, BAZ2B, PI4KB | HDAC1 10/4885HDAC2 27/4885HDAC10 49/4885 |
| US-20230227467-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | BAZ2A, BAZ2B, PI4KB | HDAC1 10/4885HDAC2 27/4885HDAC10 49/4885 |
| US-20220402934-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | BAZ2A, BAZ2B, PI4KB | HDAC1 10/4885HDAC2 27/4885HDAC10 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.