Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 14/20 | 0.51 |
| ▸ | CDK9 | P50750 | 9/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.51 |
| ▸ | CDK7 | P50613 | 6/20 | 0.50 |
| ▸ | CDK1 | P06493 | 5/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.50 |
| ▸ | CCNH | P51946 | 4/20 | 0.50 |
| ▸ | CDK4 | P11802 | 8/20 | 0.49 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CCND3 | P30281 | 1/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12842041 | 0.92 | CDK2 (0.58) | CDK2CDK9CCNT1CCNA2CDK7 | |
| SCHEMBL2075598 | 0.87 | CDK2 (0.65) | CDK2CDK9CCNT1CCNA2CDK7 | |
| SCHEMBL12842003 | 0.87 | CDK2 (0.55) | CDK2CDK9CCNT1CCNA2CDK7 | |
| SCHEMBL14044688 | 0.85 | CDK2 (0.57) | CDK2CDK9CCNT1CCNA2CDK7 | |
| SCHEMBL12842295 | 0.85 | CDK2 (0.53) | CDK2CDK9CCNT1CCNA2CDK7 | |
| SCHEMBL12842301 | 0.84 | CDK2 (0.56) | CDK2CDK9CCNT1CCNA2CDK7 | |
| SCHEMBL2075808 | 0.83 | CDK2 (0.51) | CDK2CDK9CCNT1CCNA2CDK7 | |
| SCHEMBL12842044 | 0.82 | CDK2 (0.50) | CDK2CDK9CCNT1CCNA2CDK7 | |
| SCHEMBL2076824 | 0.81 | CDK2 (0.57) | CDK2CDK9CCNT1CCNA2CDK7 | |
| SCHEMBL2074184 | 0.80 | CDK2 (0.63) | CDK2CDK9CCNT1CCNA2CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897605-B2 | Pyrimidine compounds | CYCLACEL LIMITED (GB) | 2011-03-01 | — | — | US | disclosed |
| US-20080287439-A1 | Pyrimidine compounds | CYCLACEL LIMITED (GB) | 2008-11-20 | — | — | US | disclosed |
| US-7432260-B2 | Pyrimidine compounds | CYCLACEL LIMTED (GB) | 2008-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287439-A1 | Pyrimidine compounds | CDK2, CCNI, CDK6 | CDK2 1/4885CDK9 5/4885CCNT1 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.